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transientpotassiumchannelmaybe involvedinclassical investi-
gated the effects of in vivo 4-AP administration(0.5 mg/kg)on classical con-
ditioning of the rabbit nictitating membrane response using a battery of tests de-
signed to assess the associative,sensory and motor contributors of 4-AP to re-
sponding.4-AP enhanced bothclassical conditioning and conditioning-specific
reflex modification compared to asaline vehicle control and these effects hadsev-
eral nonassociative components including an increase in the frequency ofrespond-
ing to the conditioned and unconditionedstimulus suggesting asensitizing effectof
the gh 4-AP can have peripheral effects,itmay also modify cere-
bellar excitability or hippocampal neurotransmitter balance resulting inheightening
responsiveness to stimulation.
P050032
Experimental studies on the modulatory role of nitric oxide in stress suscepti-
bility and adaptation
Kavita Gulati＊andArunabhaRayDepartmentofPharmacology,Vallabhbhai Pa-
tel Chest Institute,University of Delhi,Delhi-110007,India(＊Corre-
spondence)
Emotionality is relatedtostress susceptibility andthepresentexperimentalstudye-
valuated the modulatory role of nitric oxide(NO)in the regulation ofstress sus-
ceptibility and rats were screened as“high”and“low”emo-
tional and assay of brain homogenates showed that brain NO metabolites(NOx)
levels were lower in“high”,as compared to“low”emotional r,re-
straintstress(RS)suppressed(a)the number of entries/time spent in the open
arms of the elevated plus maze(EPM)and(b)NOx levels in brain ho-
NO precursor,L-arginine reversed both RS-induced behav-
ioral and biochemical changes,whereas,the NOS inhibitor,L-NAME,pro-
ducedopposite c RS attenuated the observed acute RS-induced
behavioral and biochemical changes and these were predictably modulated by NO
-ergic restraint stress(CRS)consistently induced gastric lesions
which were attenuated by L-arginine and aggravated by re
to chronic RS reduced theseverity ofCRS induced gastric lesions,and this adap-
tive response was facilitated by L-arginine and blocked by re-
sults indicate the involvement of NO as a modulator of stress susceptibility and
adaptation.
Key Words:Nitric Oxide,NO modulators,Stress Adaptation
The authors thank the nce and Technology,New Delhi,for finan-
cial support
P050033
The pharmacokinetic-pharmacodynamic(PK/PD)relationship of di-
azepam in rats with anxiety after exposure to repeated stress.
Rheeders Malie＊,Brand Linda,Myburgh Jacolene,Harvey on of
Pharmacology,North-West University,Potchefstroom.
The study investigatedthePK/PDrelationshipofdiazepamafteracute andchronic
treatment inmale Sprague-Dawley rats by using the elevated plus maze(EPM)
as a pharmacodynamic endpoint
the mostpopular
herbal medicinal products in the various European countries.
Hawthorn has been used for its several pharmacological effects more than 700
years as ghvarious pharmacological activities ofHawthorn
have been reported previously,to the best of our knowledge,there have beenno
reports related to its analgesic we aimed to investigate the analgesic
activity of plantseed sic activity ofmorphine(2 mg/kg)and the
extract(1-1000 mg/kg)were measured by tail-clip and tail-immersion
ne(5 mg/kg)was used as opioid tail clip tests,10
-1000 mg/kg doses of the extract showed analgesic activity,whereas its 1mg/
kg dose did ne antagonized its analgesic analgesic activity
was observed 50value ofthe extractwas estimatedhigher
than 1000 mg/ importantfor the developmentofnew analgesic drugs,
this is the first report for the analgesic activity ofHawthornseeds possibly due to
endogenous opioid r,further studies are necessary.
Key words:Hawthorn,Crataegus,analgesia
P050036
Analgesic and Sedative Activity of2-(2-Hydroxynaphthalen-1-yl)-5,6
-dichloro-(1H)-benzimidazole(HNDCB)
Demir Umide1＊,Can Ozgur Devrim2,Ozkay Yusuf3,Benkli Kadriye3,Ilhan
Isikdag3,Ozturk u Univ., Pharmacy,
Pharmacology,26470 Eskisehir,u Univ.,PlantDrug and
Scientific ResearchCentre 26470 Eskisehir,u Univ.,Fac.
ofPharmacy,maceutical Chemistry,26470 Eskisehir,TURKEY.
Benzimidazole derivatives are compounds having potential pharmacological effects
such as analgesic,antiinflammatory,sedative,selective 5-HT4receptor antago-
a benzimidazole derivative,we have synthesizedHNDCB forscreening
its analgesic andsedative study,HNDCB(500 mg/kg)was in-
vestigated for possible analgesic,skeletal muscle relaxant and sedative effects.
Tail-clip and tail-immersion tests,activity cage and rota rod measurements
were appliedfor these ne(1 mg/kg)and diazepam(2 mg/kg)
were used as sic effect was observed both in tail-clip and tail
-immersion icant decreases in the horizontal and vertical spontaneous
activities were observed al musclerelaxationwas more than
control,but less than conclusion,HNDCB shows analgesic activi-
ion in the locomotor activity and grip strength also shows the central
nervous system depressant r studies are in progress to examine the
pharmacological activities of other compounds in the same chemical group.
Keywords:benzimidazole derivatives,central nervous system,animal behavior
88XVth World Congress of Pharmacology:Meeting Abstracts