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2020年09月09日 08:32
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深圳人事考试网-昆山一中


30s

Good afternoon, everyone. The title of the paper is Visible Microspectroscopy for
Diagnosis of Gastric Precancer. Its author is Liu Yong from Department of Physics, Zhao
qing University. It’s presented by Li Mengfan from CAS, Hefei Institutes of Physical
Science. You can know more about cancer and the new method to diagnose gastric
precancer after reading this paper.

58s

Cancer is very common among human beings. It is mostly related to the habit of the
patients, the job, the environment, the drinking water and the soil matters, too. If a person
is affected by certain bacteria, he may also get gastric cancer. Bad habits like smoking,
drinking, mental tension, eating improperly and living irregularly increase the possibility of
having cancer. Before specific treatment, the doctor should make sure whether the patient
has cancer and where the focus is. The method used to diagnose cancer and locate the


cancerous area is very important.



42s

Before we design a method to diagnose cancer, we should know more about cancer like
where it starts and what it causes.
Firstly, about 90% of the human’s cancer start from the epithelial layer of skin, internal
organs and tubular organs in the body. Secondly ,
cancer usually accompanied by the
changes of organization structure in the cell level.
So,
the changes which appear in the
structure of organization and chemical composition provides important evidence for diagnosis
of precancer.


42s


Normal method to diagnose gastric precancer is
Reflectance spectroscopy. It’s very
prospective in early diagnosis of cancer and is commonly used these years.

One of the most common technology is
diffuse reflectance visible spectroscopy, it can
acquire the approximate information of the target tissue. This method is low cost, fast and
non-invasive, it provides important means for diagnosis of malignant damage of
organization of human organs. However, there are also some disadvantages of this
method which need to be improved.

55s

This is the system of diffuse reflectance spectroscopy, the light beam emitted from the tungsten
halogen lamp is guided into the integral ball by the source fiber. The light come out of the integral
ball irradiate the standard board, the reflected light of the standard board is treated as the
background. Then take target tissue substitute for the standard board, and scan the reflected light
of it. The reflected light spectra of the gastric tissue mucosal layer and the submucosa layer is
guided into the spectrometer by the collector fiber. The spectrometer and the computer is
connected by USB, spectrum can be processed using computer.

36s



First of all, only
average visible spectrum of the target tissue can be acquired, it means that the
docters cannot make out the location of the cancerous tissue precisely.

What’s more, the device is easy to be affected by changes of optical path length induced by
different set-up of prober and the variation of hemoglobin concentration due to the
pressure between prober and tissue.

50s

To avoid the problems of the commonly used techniques, diffuse reflectance visible
spectroscopy, scientists do a lot of researches to find out a new way to diagnose
precancer.
The new method is Visible Microspectroscopy. The visible microspectroscopic
measurement device is accomplished on the basis of fiber confocal microscope, its 3-d
imaging principle devote to the optical tomography ability of the system.
The visible microspectrum of cancerous and normal tissue can be analysed and
contrasted, so it’s more useful than the normal method.


45s

This is the structure of the visible microspectroscopy device .
The fiber coupler can separate the lighting beams from the signal beam. The two lens can
focus the light on the tissue ,
The 3-D electronic controlled platform move along the direction of optic axis, so that the
device can acquire the visible microspectroscopy signal of the sample in different depth,
precisely locate the boundary of the cancerous signal measured from different
position can be stored in the computer after analysed by the spectrometer.

31s

This is the spectrum chart of the normal tissue and cancerous tissue, they are analyzed by
the spectrometer before being transmitted to the computer. The upper chart is the visible
spectrum of normal tissue, it is regular. Contrasting to this, in the nether chart, the
spectrum of the cancerous area shows that the strength of reflected light grows as the
wave length grows.
49s



In comparison with the normal method, there are a lot of advantages of the new
method.
Firstly, the structure of visible microspectroscopy device is very simple. The main parts
consist of source, fiber coupler, 3-D electronic controlled platform, spectrometer and the
computer.
Secondly, the 3-D space microspectrum can be acquired , which can help the doctors
efficiently make out whether the gastric tissue is cancerous.
What’s more, the optical tomography ability enabled the device to precisely locate the
edge of the cancerous area.

32s
i.
ii.
iii.

In conclusion, the main goal of this research is to find a new way to diagnose the
gastric precancer.
The spectrum of the normal and cancerous gastric tissues which can be
measured by visible microspectroscopy in cell level is the central idea .
This new method can obtain the cell level information, and is not affected by


changes of optical path length and hemoglobin concentration.

50s

i. The device is very simple, so it can have a small size, which can reduce the
sufferings of can efficiently make out whether the tissue is canceration.
ii. Besides, the 3-D space microspectrum and optical tomography ability can make
the device accurately distinguish the cancerous tumor area from the normal tissue in cell
level, thus the boundary of the cancerous tissue can be ascertained accurately.
iii. The result of the research shows that this device may be used to non-invasively
diagnosis of early gastric cancer.
20s

This device is only researched in the lab, there are still a lot of works to do to make this device
applied into practice. So, special design of this device should be made which can be applied
to the medical diagnosis.

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